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This article is part of the supplement: Eighteenth Annual Computational Neuroscience Meeting: CNS*2009

Open Access Poster presentation

Spike-timing prediction in a neuron model with active dendrites

Richard Naud1*, Brice Bathellier2 and Wulfram Gerstner1

  • * Corresponding author: Richard Naud

Author Affiliations

1 Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne 1015, Switzerland

2 Institut fur Zoologie, Universitaet Wien, Althanstrasse 14, A-1090, Wien, Austria

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BMC Neuroscience 2009, 10(Suppl 1):P29  doi:10.1186/1471-2202-10-S1-P29

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/10/S1/P29


Published:13 July 2009

© 2009 Naud et al; licensee BioMed Central Ltd.

Poster presentation

A complete model for single neurons must reproduce correctly the firing of spikes and bursts. Yet it must remain simple enough to be tractable in large-scale simulations. We present a study of a simplified model of Layer V pyramidal cells of the cortex with active dendrites. We hypothesized that we can model the soma and its apical trunk with only two compartments without significant loss in the accuracy of spike-timing predictions. The model is based on experimentally measurable impulse-response functions [1], which transfer the effect current injected in one compartment to the other. Each compartment was modeled with a pair of non-linear differential equations [2] with a small number of parameters that approximate the Hodgkin-and-Huxley equations. The predictive power of this model was tested on electrophysiological experiments where noisy current was injected in both the soma and the apical dendrite simultaneously [3].

References

  1. Segev I, Rall W, Rinzel J:

    The Theoretical Foundation of Dendritic Function. 1995. OpenURL

  2. Brette R, Gerstner W:

    J Neurophys. 2005. OpenURL

  3. Larkum ME, Senn W, Luscher H:

    Cereb Cortex. 2004. PubMed Abstract | Publisher Full Text OpenURL