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Open Access Highly Accessed Methodology article

Imaging cortical activity following affective stimulation with a high temporal and spatial resolution

Julian Keil1*, Hannah Adenauer1, Claudia Catani2 and Frank Neuner2

Author Affiliations

1 Department of Psychology, University of Konstanz and Center for Psychiatry Reichenau, D-78457 Konstanz, Germany

2 Department of Psychology, University of Bielefeld, D-33501 Bielefeld, Germany

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BMC Neuroscience 2009, 10:83  doi:10.1186/1471-2202-10-83

Published: 17 July 2009

Abstract

Background

The affective and motivational relevance of a stimulus has a distinct impact on cortical processing, particularly in sensory areas. However, the spatial and temporal dynamics of this affective modulation of brain activities remains unclear. The purpose of the present study was the development of a paradigm to investigate the affective modulation of cortical networks with a high temporal and spatial resolution. We assessed cortical activity with MEG using a visual steady-state paradigm with affective pictures. A combination of a complex demodulation procedure with a minimum norm estimation was applied to assess the temporal variation of the topography of cortical activity.

Results

Statistical permutation analyses of the results of the complex demodulation procedure revealed increased steady-state visual evoked field amplitudes over occipital areas following presentation of affective pictures compared to neutral pictures. This differentiation shifted in the time course from occipital regions to parietal and temporal regions.

Conclusion

It can be shown that stimulation with affective pictures leads to an enhanced activity in occipital region as compared to neutral pictures. However, the focus of differentiation is not stable over time but shifts into temporal and parietal regions within four seconds of stimulation. Thus, it can be crucial to carefully choose regions of interests and time intervals when analyzing the affective modulation of cortical activity.