Exercise effect on the amphetamine-induced locomotor activity in the chronic MPD. The amphetamine (3 mg/kg, i.p.)-induced locomotor activity in the chronic MPD mice 11 weeks after MPTP/probenecid treatment was significantly lower than that of the chronic probenecid-treated control mice (*P = 0.009). Following 11 weeks of exercise training, no statistically significant recovery of the amphetamine-stimulated movement was observed when comparing to the sedentary chronic MPD (**P = 0.186).
Pothakos et al. BMC Neuroscience 2009 10:6 doi:10.1186/1471-2202-10-6