Exercise effect on the spontaneous locomotor activity in the chronic MPD. The horizontal movement expressed as cumulative distance traveled by each animal was recorded over 180 min. The spontaneous locomotor activity in the chronic MPD mice 11 weeks after MPTP/probenecid treatment was significantly lower than that of the chronic probenecid-treated control mice (*P = 0.03). Continuous exercise for 11 weeks after MPTP/probenecid treatment in the chronic MPD completely reversed the spontaneous movement deficit as detected in the sedentary chronic MPD group (**P = 0.02).
Pothakos et al. BMC Neuroscience 2009 10:6 doi:10.1186/1471-2202-10-6