Schematic representation of the experimental design. Mice underwent surgery during which they received stereotaxic intracerebroventricular injections of either vehicle or murine-p75-saporin (mu-p75-SAP) immunotoxin. After 10 days for recovery, mice were exposed to either immobilised running wheels or freely moving running wheels. Following 12 days of exposure to the running wheels, the mice received intraperitoneal injections of 5-bromodeoxyuridine (BrdU). The mice were sacrificed for perfusion fixation either 24 hours or 4 weeks after injection of BrdU.
Ho et al. BMC Neuroscience 2009 10:57 doi:10.1186/1471-2202-10-57