Table 2

Brain areas with regional white matter volume changes and MTR reductions (TS versus controls)

Cluster size

Regions (Brodmann areas)

MNI-Space

t-value

p-value

(SVC)


x

y

z


WMV: controls > TS

157

Right inferior frontal gyrus (9)

44

3

25

4.35

0.010

81

Left superior frontal gyrus (6)

-16

15

54

4.05

0.021

33

Left precentral gyrus (6)

-25

-20

70

3.93

0.027

115

Right anterior corpus callosum

7

34

10

3.92

0.028

79

Left lingual gyrus (18)

-32

-77

-12

3.82

-

WMV: TS > controls

267

Left postcentral gyrus (43)

-54

-10

20

5.02

0.005

344

Left precentral gyrus (6)

-26

-12

53

4.00

0.023

Left middle frontal gyrus (6)

-19

-11

62

3.74

0.031

42

Left precentral gyrus (4)

-45

-18

38

3.60

0.056

34

Right parahippocampal gyrus (30)

27

-46

6

3.49

0.060

10

Right precentral gyrus (44)

49

10

11

3.39

0.085

MTR maps: controls > TS

99

Right medial frontal gyrus (9)

17

32

37

3,75

0.036

33

Right inferior frontal gyrus (46)

40

32

12

3,65

0.045

33

Left inferior frontal gyrus (46)

-41

24

13

3,63

0.041

17

Right cingulate gyrus (32)

11

22

43

3,45

0.048


MNI = Montreal Neurological Institute, SVC = small volume correction, WMV = white matter volume, MTR = magnetization transfer ratio, TS = Tourette syndrome. No regions displayed significant regional increases in MTR maps for TS patients versus controls.

Müller-Vahl et al. BMC Neuroscience 2009 10:47   doi:10.1186/1471-2202-10-47

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