Table 1

Brain areas with regional gray matter volume reductions in TS patients compared to normal subjects

Cluster size

Regions (Brodmann areas)

MNI-Space

t-value

p-value

(SVC)


x

y

z


254

Left postcentral gyrus (43)

-55

-8

20

5.04

0.009

83

Right precentral gyrus (4)

38

-20

47

4.54

0.031

60

right cingulate gyrus (32)

9

22

31

4.01

0.049

224

Left caudate (body)

-15

14

13

4.00

0.018

Left caudate (head)

-10

11

3

3.54

57

Left middle frontal gyrus (6)

-36

12

56

4.00

0.018

180

Left precentral gyrus (4)

-45

-18

36

3.96

0.020

Left precentral gyrus (4)

-52

-15

40

3.52

58

Right middle frontal gyrus (6)

44

6

57

3.96

0.020

152

Right precentral gyrus (6)

59

-13

38

3.95

0.020

43

Right precentral gyrus (4)

45

-19

38

3.95

0.017

25

Right postcentral gyrus (3)

41

-26

58

3.68

0.014

14

Right medial frontal gyrus (8)

10

29

48

3.62

0.042

20

Left cingulate gyrus (32)

-9

12

39

3.61

0.043


Cluster size = number of voxels; x, y, z = Coordinates (in mm) of significant local maxima are given for information in MNI space (Montreal Neurological Institute, http://www.bic.mni.mcgill.ca webcite). Significant local maxima more than 8 mm apart were translated to brain anatomy by converting their coordinates from MNI space to Talairach space http://www.talairach.org/ webcite allowing for a search radius of 9 mm for nearest gray matter. For regions where an effect was hypothesized (see introduction), a small volume correction (SVC) was performed. P values are given after family wise error (FWE) correction for the particular volume. No regions displayed significant regional increases in GMV for TS patients versus controls.

Müller-Vahl et al. BMC Neuroscience 2009 10:47   doi:10.1186/1471-2202-10-47

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