Table 1

Parameter changes to simulate stress and ageing

Ageing Parameter Changes

Default Value

New Value/Comments


khos

1.6 × 10-6

8.1 × 10-6 at 60 years

5.3 × 10-5 at 80 years

ktfs

2.5 × 10-6

9 × 10-6 at 60 years

3.4 × 10-6 at 80 years

Acute Stress Intervention

Hippocampus Output Chronic Stress Intervention

kcor

2.4 × 10-3

Increased default value every year by 5.0 × 10-5 from 60–80 years then reduced parameter by 3.24 × 10-5 to mark cessation of chronic stress

Hippocampus output Acute Stress Intervention

kcor

2.4 × 10-3

Increased default value every year by 3.0 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of chronic stress

Hippocampus Output Acute Stress Intervention

kcor

2.4 × 10-3

Increased default value every year by 1.55 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of acute stress

Hippocampus output chronic stress intervention

kcor

2.4 × 10-3

Increased default value every year by 2.05 × 10-5 from 60–80 years then reduced parameter by 1.5 × 10-5 to mark cessation of chronic stress

Hippocampus output with PA intervention for acute stress

kcor

2.4 × 10-3

Decreased value used for acute stress intervention by 2.8 × 10-5 on 60 years 3.0 × 10-6

Hippocampus Output with PA intervention for chronic stress

kcor

2.4 × 10-3

Decreased value used for acute stress intervention by 1.0 × 10-5 on 60 years and 80 2.5 × 10-6

Hippocampus Volume With PA intervention for chronic stress

kcor

2.4 × 10-3

Decreased value used for acute stress intervention by 5 × 10-8 on 60 years and 80 years 5 × 10-5

Hippocampus Volume With PA intervention for acute stress

kcor

2.4 × 10-3

Decreased value used for acute stress intervention by 3.0 × 10-6 on 60 years and 80 8.0 × 10-8


McAuley et al. BMC Neuroscience 2009 10:26   doi:10.1186/1471-2202-10-26

Open Data