Open Access Highly Accessed Research article

Perisylvian white matter connectivity in the human right hemisphere

Alireza Gharabaghi1*, Frank Kunath12, Michael Erb2, Ralf Saur2, Stefan Heckl2, Marcos Tatagiba1, Wolfgang Grodd2 and Hans-Otto Karnath3

Author Affiliations

1 Functional and Cognitive Neurosurgery Unit, Department of Neurosurgery and Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany

2 Section Experimental NMR of the CNS, Department of Neuroradiology, University of Tübingen, 72076 Tübingen, Germany

3 Section of Neuropsychology, Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany

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BMC Neuroscience 2009, 10:15  doi:10.1186/1471-2202-10-15

Published: 3 March 2009



By using diffusion tensor magnetic resonance imaging (DTI) and subsequent tractography, a perisylvian language network in the human left hemisphere recently has been identified connecting Brocas's and Wernicke's areas directly (arcuate fasciculus) and indirectly by a pathway through the inferior parietal cortex.


Applying DTI tractography in the present study, we found a similar three-way pathway in the right hemisphere of 12 healthy individuals: a direct connection between the superior temporal and lateral frontal cortex running in parallel with an indirect connection. The latter composed of a posterior segment connecting the superior temporal with the inferior parietal cortex and an anterior segment running from the inferior parietal to the lateral frontal cortex.


The present DTI findings suggest that the perisylvian inferior parietal, superior temporal, and lateral frontal corticies are tightly connected not only in the human left but also in the human right hemisphere.