Motor and neurological performance of stroke rats. Both motor and neurological dysfunctions were significantly ameliorated by low dose minocycline (20 mg/kg, i.v.), as revealed by elevated body swing test (EBST; A) and Bederson test (B). In contrast, high dose minocycline (100 mg/kg, i.v.) significantly exacerbated neurological deficits and slightly worsened motor deficits. Data are shown as the mean values ± SEM (*p < 0.05).
Matsukawa et al. BMC Neuroscience 2009 10:126 doi:10.1186/1471-2202-10-126