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Open Access Highly Accessed Research article

Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury

Dong H Hwang1, Byung G Kim12*, Eun J Kim1, Seung I Lee1, In S Joo2, Haeyoung Suh-Kim3, Seonghyang Sohn4 and Seung U Kim156*

Author Affiliations

1 Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea

2 Department of Neurology, Ajou University School of Medicine, Suwon, Korea

3 Department of Anatomy, Ajou University School of Medicine, Suwon, Korea

4 Laboratory of Cell Biology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea

5 Medical Research Institute, Chungang University School of Medicine, Seoul, Korea

6 Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada

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BMC Neuroscience 2009, 10:117  doi:10.1186/1471-2202-10-117

Published: 22 September 2009

Additional files

Additional file 1:

Immunocytochemical detection of differentiation into mature astrocytes or neurons. F3 (A, C) or F3.Olig2 (B, D) cells were grown on coverslips in DMEM with 2% FBS for 5 days and then fixed with 4% paraformaldehyde. Then the cells were stained with anti-GFAP (A, B) or anti-MAP2 (C, D) antibodies. Some of F3 cells showed differentiation into astrocyte or neurons, but virtually no F3.Olig2 cells were immunoreactive against GFAP or MAP2.

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