Table 1

Plasma concentrations of caffeine and its metabolite theophylline in caffeine-treated rats.

Caffeine (μg/ml)

Theophylline (μg/ml)

Caffeine-treated rats with ventriculomegaly

0.037 ± 0.008

0.68 ± 0.089

Caffeine-treated rats without ventriculomegaly

0.010 ± 0.006

0.34 ± 0.174

Rats were treated with caffeine (0.6 g/L) for 3 weeks and were sacrificed 3 days after MRI imaging. Means ± SEM of 10 rats in each group

Han et al. BMC Neuroscience 2009 10:110   doi:10.1186/1471-2202-10-110