Research article
Regulation of cerebrospinal fluid production by caffeine consumption
-
* Corresponding author: Sae-Ock Oh hedgehog@pusan.ac.kr
- † Equal contributors
1 Department of Anatomy, School of Medicine, Pusan National University, Busan, South Korea
2 Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Busan, South Korea
3 Department of Radiology, School of Medicine, Pusan National University, Busan, South Korea
4 Department of Biomedical Engineering, School of Medicine, Pusan National University, Busan, South Korea
BMC Neuroscience 2009, 10:110 doi:10.1186/1471-2202-10-110
Published: 3 September 2009Additional files
Additional file 1:
There was no significant difference in the water uptake between the control and caffeine-treated groups. Water uptake was examined everyday for 3 weeks. Caffeine (0.3 or 0.6 g/L) was added to the drinking water. Values are expressed as the means ± SEM of 10 rats in each group.
Format: PDF Size: 37KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2:
There was no significant difference in weight gain between the control and caffeine-treated groups. The weight gain was measured every week for 3 weeks. Caffeine (0.3 or 0.6 g/L) was added to the drinking water. Values are expressed as the means ± SEM of 8 rats in each group.
Format: PDF Size: 21KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 3:
Acute treatment with caffeine (10 mg/kg) did not cause a significant change in the mean arterial blood pressure (MABP). Caffeine was injected intravenously. Values are expressed as the means ± SEM of 8 rats in each group.
Format: PDF Size: 21KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 4:
Acute treatment with caffeine (10 mg/kg) did not cause a significant change in the respiratory rate. The respiratory rate was counted for 1 min. The count was based on the up-and-down movement of the abdomen associated with the animal's breathing. Caffeine was injected intravenously. Values are expressed as the percentage of the control (n = 8).
Format: PDF Size: 21KB Download file
This file can be viewed with: Adobe Acrobat Reader