Table 5

25 Point Rat Behavior Scale Based on Feldman and colleagues {Feldman1996}

Characteristic

Points

Mobility

Inability to exit from a circle 50 cm in diameter when placed in center

Within 30 minutes

1

Within 60 minutes

1

At > 60 minutes

1

Hemiplegia (inability to resist forced changes in position)

1

Inability to walk straight when placed on floor

1

Inability to move

1

Reflexes

Flexion of hindlimb when raised by tail

1

Loss of startle reflex

1

Loss of righting reflex

For 20 min

1

For 40 min

1

For 60 min

1

Behavior

Loss of seeking behavior

1

Prostration

1

Functional tests

Failure in beam walking task

8.5 cm wide

1

5 cm wide

1

2.5 cm side

1

Failure in beam balancing task (1.5 cm wide)

for 20 sec

1

for 40 sec

1

for 60 sec

1

Stability on balance beam (1.5 cm wide)

able to walk, normal gait

0

able to walk, impaired gait

1

unable to walk, steady balance on beam

1

unable to walk, steady balance, all limbs on beam

1

unable to walk, unsteady balance, unable to place all limbs on beam 1

1

Effort on beam balance (1.5 cm wide)

unable to stay on the board

1

unable to try to stay on the board

1

Total

25

Jeon et al. BMC Neuroscience 2009 10:103   doi:10.1186/1471-2202-10-103