Additional file 1.

Effect of the E2 mutant in hPer3 on circadian expression of luciferase. Wild-type (gray letters) and mutant (black letters) sequences of hPer3 EE-element and their flanking sequences are shown in upper panel. The core sequence within the EE-element is shown in capital letters. Bioluminescence monitoring of the hPer3 EE-element-Luc construct was performed by using IV-ROMS (black; mutant, gray; wild-type). The abscissa presents "day"; and the ordinate shows "relative luciferase intensity". First peak values of the curves were set to 1.

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Nakahata et al. BMC Molecular Biology 2008 9:1   doi:10.1186/1471-2199-9-1