Research article
Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential
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* Corresponding author: Thierry Léveillard leveilla@st-antoine.inserm.fr
1 Divisions of Bioinformatics and Biochemistry, Swiss Institute of Bioinformatics, University of Basel, CH-4056 Basel, Switzerland
2 Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Inserm U592, Université Pierre et Marie Curie, 75571 Paris, France
3 Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch cedex, France
4 Department of Computer Science, Genome Center, University of California, Davis, CA 95616, USA
5 Novartis Institutes for Biomedical Research, Basel 4002, Switzerland
6 Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
7 Institute of Ophthalmology, University College of London, UK
8 Fovea-Pharmaceuticals – 12 rue Jean Antoine Le Baif – 75013 Paris
BMC Molecular Biology 2007, 8:74 doi:10.1186/1471-2199-8-74
Published: 31 August 2007Additional files
Additional file 1:
Gene structure and exon coordinates of RdCVF and RdCVF2 genes. The table reports the exon positions of the RdCVF(2) isoforms on 13 vertebrate genomes. The genome versions are indicated at the right.
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Additional file 2:
Phylogenetic tree of the RdCVF and RdCVF2 proteins. The phylogenetic tree based on the multiple alignment displayed in Figure 2 panel a was done using PhyloWin. The name, organism and accession number are given for each protein. Bootstrap values are indicated at nodes.
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Additional file 3:
Time course expression of RdCVF2 and Rhodopsin. Both graphs correspond respectively to RdCVF2 and Rhodopsin prosets. The wt and rd1 are on the same genetic background (C3H).
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Additional file 4:
Tissue distribution of RdCVF and RdCVF2 mRNAs. The table describes tissue expression of the EST and mRNA sequences available in the EMBL databases corresponding to RdCVF(-L/-S/2-L/2-S) transcripts.
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