Table 1

Doubling time estimation of P. falciparum mutant clones

Clone ID

Doubling time estimate (hours)

Standard error

95% CI

P value

t value

df

A5

22.07

0.26

21.53

22.60

0.00007

7.4656

7

B3

17.89

0.06

17.77

18.00

0.97376

-2.3316

7

B4

18.45

0.10

18.25

18.66

0.41380

0.2261

7

B7

19.70

0.17

19.34

20.06

0.00368

3.7297

7

E6

19.28

0.12

19.04

19.52

0.00565

3.4086

7

F3

21.98

0.17

21.64

22.33

0.00001

10.5459

7

F10

17.83

0.09

17.64

18.03

0.97735

-2.4318

7

G1

18.17

0.08

18.02

18.33

0.83353

-1.0400

7

H11

18.03

0.11

17.80

18.26

0.89928

-1.4098

7

WT

18.39

0.06

18.26

18.52

N/A: WT is reference

Doubling times for mutant parasite clones were estimated using their respective best-fit growth curves (See Fig. S1 in Additional file 2). Simple two-tailed t-test was then used to test the significance of differences in doubling time of mutant clones with wild type (WT) P. falciparum clones (average of three NF54 clones) as the reference. Significant P values, based on alpha = 0.05, are highlighted in bold.

Balu et al. BMC Microbiology 2009 9:83   doi:10.1186/1471-2180-9-83