Fc- and complement-receptor activation stimulates cell cycle progression of human peripheral blood monocytes from G1 to S. Phagocytosis of C. neoformans strain 20467 mediated by 18B7 and C. neoformans strain H99 mediated by human serum was followed by an increase in S phase cell distribution of human monocytes. Percentage of G1, S and G2 cells are indicated in the control group (C. neoformans added – and C. neoformans ingested -) and the phagocytosis assay group (C. neoformans added +) which was further separated into the non-phagocytic (C. neoformans added + and C. neoformans ingested -) and the phagocytic (C. neoformans added + and C. neoformans ingested +) groups. Comparison of G1, S and G2 percentages between non-phagocytic and phagocytic groups revealed statistically significant differences (p < 0.001).
Alvarez et al. BMC Microbiology 2009 9:51 doi:10.1186/1471-2180-9-51