Intracellular accumulation of levofloxacin and effect of the addition of reserpine. Effect of the addition of reserpine on the intracellular accumulation of levofloxacin by B. cenocepacia J2315, D1, and D4 deleted mutants. Levofloxacin (40 μg/ml) was added to the assay mixture to initiate the assay, and reserpine (8 μg/ml) was added at the time point indicated by the arrow. Shown is the mean and standard deviation of values derived from three independent experiments.
Buroni et al. BMC Microbiology 2009 9:200 doi:10.1186/1471-2180-9-200