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Open Access Research article

Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein

Haiyan Dong12, Ye Hu3, Feng Xue12, Dexter Sun4, David M Ojcius5, Yafei Mao12 and Jie Yan12*

Author Affiliations

1 Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou Zhejiang, PR China

2 Department of Medical Microbiology and Parasitology, Medical College of Zhejiang University, Hangzhou Zhejiang, PR China

3 Medical School of Jinhua Professional Technique College, Jinhua Zhejiang, PR China

4 New York Presbyterian Hospital & Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY, USA

5 School of Natural Sciences, University of California, Merced, CA, USA

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BMC Microbiology 2008, 8:223  doi:10.1186/1471-2180-8-223

Published: 17 December 2008

Additional files

Additional file 1:

Full image of maximum parsimony trees for ompL1 nucleotide sequences (A) and its amino acid sequences (B) of 15 standard strains. This figure showed the phylogenetic relationship of nucleotide sequence and amino acid sequences of Chinese 15 standard strains of pathogenic leptospires.

Format: TIFF Size: 2.1MB Download file

Open Data

Additional file 2:

Full image of comparison of the predicted secondary structures and antigenic index of OmpL1 proteins. This figure showed the predicted secondary structures and antigenic index of OmpL1 proteins belongs to three gene types (ompL1/1, ompL1/2, and ompL1/3).

Format: TIFF Size: 3.3MB Download file

Open Data