Open Access Highly Accessed Research article

Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus

Sarah K Highlander13*, Kristina G Hultén2, Xiang Qin3, Huaiyang Jiang3, Shailaja Yerrapragada3, Edward O Mason2, Yue Shang3, Tiffany M Williams3, Régine M Fortunov2, Yamei Liu6, Okezie Igboeli3, Joseph Petrosino1, Madhan Tirumalai6, Akif Uzman5, George E Fox6, Ana Maria Cardenas1, Donna M Muzny3, Lisa Hemphill3, Yan Ding3, Shannon Dugan3, Peter R Blyth3, Christian J Buhay3, Huyen H Dinh3, Alicia C Hawes3, Michael Holder3, Christie L Kovar3, Sandra L Lee3, Wen Liu3, Lynne V Nazareth3, Qiaoyan Wang3, Jianling Zhou3, Sheldon L Kaplan2 and George M Weinstock134

Author Affiliations

1 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA

2 Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA

3 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

4 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

5 University of Houston-Downtown, Houston, TX, USA

6 University of Houston, Houston, TX, USA

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BMC Microbiology 2007, 7:99  doi:10.1186/1471-2180-7-99

Published: 6 November 2007

Additional files

Additional file 1:

DNA regions present in USA300-HOU-MR but missing in USA300-HOU-MS and their presence in other sequenced staphylococcal genomes.

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Additional file 2:

Single nucleotide polymorphisms and short insertions/deletions between USA300-MR, USA300-MS and FPR3757. Alleles in other sequenced S. aureus strains are also listed.

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Additional file 3:

Predicted non-classically secreted proteins.

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