Table 4 |
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|
Drug resistance, cytoskeletal and ion transport proteins showing pH dependence under oxygen limitation |
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|
Gene |
Function |
Log2pH ratio |
||
|
|
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|
Acid up-regulated |
pH 5.7/pH 7.0 |
pH 7.0/pH 8.5 |
pH 5.7/pH 8.5 |
|
|
|
||||
|
chaB |
Regulator of Na+-Ca+/H+ antiporter |
0.80 |
||
|
chaC |
Regulator of Na+-Ca+/H+ antiporter |
0.60 |
-0.38 |
|
|
copA |
Copper-, silver-translocating P-type ATPase |
0.86 |
-0.56 |
|
|
cueR |
Activator of copper-responsive regulon genes cueO and copA |
1.31 |
-0.4 |
0.91 |
|
cusC |
Silver and copper efflux |
0.44 |
0.63 |
|
|
feoA |
ferrous iron transport protein A |
0.82 |
1.22 |
|
|
feoB |
ferrous iron transport protein B |
0.41 |
0.53 |
|
|
marR1 |
multiple antibiotic resistance protein |
0.31 |
||
|
mdtE |
MdtEF-TolC multidrug resistance efflux transporter |
3.17 |
-1.59 |
1.58 |
|
mdtF |
MdtEF-TolC multidrug resistance efflux |
2.58 |
-0.98 |
1.60 |
|
mdtG1 |
Multidrug resistance efflux transporter |
0.16 |
0.25 |
|
|
mdtI1 |
multidrug transport protein |
1.16 |
1.16 |
|
|
mdtJ1 |
multidrug transport protein |
2.91 |
3.02 |
|
|
mdtL |
Multidrug resistance efflux protein |
0.57 |
||
|
mgtA |
Mg2+ transport |
0.48 |
0.63 |
|
|
nhaA |
Na+/H+ antiporter |
1.93 |
-0.93 |
1.00 |
|
nhaB1 |
Na+/H+ antiporter |
0.41 |
0.37 |
|
|
nikA |
periplasmic binding protein for nickel |
0.7 |
0.84 |
|
|
nikB |
nickel transport |
0.50 |
0.56 |
|
|
nikC |
nickel transport |
0.70 |
0.86 |
|
|
nikD |
ATP-binding protein of nickel transport system |
0.60 |
0.74 |
|
|
nikE |
ATP-binding protein of nickel transport system |
0.45 |
0.49 |
|
|
prc |
carboxy-terminal protease for penicillin-binding protein 3 |
0.32 |
0.37 |
|
|
|
||||
|
Base up-regulated |
||||
|
|
||||
|
acrA |
acridine efflux pump |
-0.34 |
-0.35 |
-0.69 |
|
acrB |
acridine efflux pump |
-0.42 |
||
|
acrR2 |
acrAB operon repressor |
-0.93 |
-1.22 |
|
|
alx2 |
Putative metal transporter, homolog of terC (tellurium resistance) |
-0.57 |
-0.52 |
|
|
ampC |
beta-lactamase; penicillin resistance; penicillin-binding protein |
-0.24 |
-0.12 |
|
|
atpA2 |
ATP synthase, F1 alpha-subunit |
-0.66 |
||
|
atpC2 |
ATP synthase, F1 epsilon-subunit |
-0.66 |
||
|
atpD2 |
ATP synthase, F1 beta-subunit |
-0.35 |
-0.36 |
-0.71 |
|
atpF2 |
ATP synthase, F0 subunit b |
-0.46 |
-0.51 |
|
|
atpG2 |
ATP synthase, F1 gamma-subunit |
-0.66 |
||
|
atpH2 |
ATP synthase, F1 delta-subunit |
-0.42 |
-0.58 |
|
|
atpI2 |
ATP synthase subunit |
-0.53 |
||
|
chaA |
Na+-Ca+/H+ antiporter |
-0.86 |
-1.1 |
|
|
corA |
Mg2+ transport, system I |
0.10 |
-0.39 |
|
|
cutA |
divalent cation tolerance protein |
-0.27 |
-0.3 |
|
|
dacA |
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 |
-0.58 |
-0.65 |
|
|
dacC |
D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6 |
0.87 |
-1.16 |
|
|
dacD |
penicillin binding protein 6b |
-1.22 |
-0.90 |
|
|
emrA1 |
multidrug resistance secretion protein |
-0.64 |
-0.11 |
|
|
mepA1 |
murein DD-endopeptidase, penicillin-insensitive |
-0.68 |
-0.19 |
|
|
mreB2 |
regulator of ftsI, penicillin binding protein 3, septation function |
-0.53 |
-0.44 |
|
|
mreC |
rod shape-determining protein |
-0.29 |
-0.39 |
|
|
napF |
Fe-S ferredoxin-type protein |
-0.59 |
-0.14 |
|
|
napG |
ferredoxin-type protein |
-0.39 |
-0.20 |
|
|
napH |
ferredoxin-type protein |
-0.37 |
-0.20 |
|
|
|
||||
|
1Acid up-regulated with aeration [2] 2Base up-regulated with aeration [2] |
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|
Hayes et al. BMC Microbiology 2006 6:89 doi:10.1186/1471-2180-6-89 |
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