Table 4

Drug resistance, cytoskeletal and ion transport proteins showing pH dependence under oxygen limitation

Gene

Function

Log2pH ratio


Acid up-regulated

pH 5.7/pH 7.0

pH 7.0/pH 8.5

pH 5.7/pH 8.5


chaB

Regulator of Na+-Ca+/H+ antiporter

0.80

chaC

Regulator of Na+-Ca+/H+ antiporter

0.60

-0.38

copA

Copper-, silver-translocating P-type ATPase

0.86

-0.56

cueR

Activator of copper-responsive regulon genes cueO and copA

1.31

-0.4

0.91

cusC

Silver and copper efflux

0.44

0.63

feoA

ferrous iron transport protein A

0.82

1.22

feoB

ferrous iron transport protein B

0.41

0.53

marR1

multiple antibiotic resistance protein

0.31

mdtE

MdtEF-TolC multidrug resistance efflux transporter

3.17

-1.59

1.58

mdtF

MdtEF-TolC multidrug resistance efflux

2.58

-0.98

1.60

mdtG1

Multidrug resistance efflux transporter

0.16

0.25

mdtI1

multidrug transport protein

1.16

1.16

mdtJ1

multidrug transport protein

2.91

3.02

mdtL

Multidrug resistance efflux protein

0.57

mgtA

Mg2+ transport

0.48

0.63

nhaA

Na+/H+ antiporter

1.93

-0.93

1.00

nhaB1

Na+/H+ antiporter

0.41

0.37

nikA

periplasmic binding protein for nickel

0.7

0.84

nikB

nickel transport

0.50

0.56

nikC

nickel transport

0.70

0.86

nikD

ATP-binding protein of nickel transport system

0.60

0.74

nikE

ATP-binding protein of nickel transport system

0.45

0.49

prc

carboxy-terminal protease for penicillin-binding protein 3

0.32

0.37


Base up-regulated


acrA

acridine efflux pump

-0.34

-0.35

-0.69

acrB

acridine efflux pump

-0.42

acrR2

acrAB operon repressor

-0.93

-1.22

alx2

Putative metal transporter, homolog of terC (tellurium resistance)

-0.57

-0.52

ampC

beta-lactamase; penicillin resistance; penicillin-binding protein

-0.24

-0.12

atpA2

ATP synthase, F1 alpha-subunit

-0.66

atpC2

ATP synthase, F1 epsilon-subunit

-0.66

atpD2

ATP synthase, F1 beta-subunit

-0.35

-0.36

-0.71

atpF2

ATP synthase, F0 subunit b

-0.46

-0.51

atpG2

ATP synthase, F1 gamma-subunit

-0.66

atpH2

ATP synthase, F1 delta-subunit

-0.42

-0.58

atpI2

ATP synthase subunit

-0.53

chaA

Na+-Ca+/H+ antiporter

-0.86

-1.1

corA

Mg2+ transport, system I

0.10

-0.39

cutA

divalent cation tolerance protein

-0.27

-0.3

dacA

D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5

-0.58

-0.65

dacC

D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6

0.87

-1.16

dacD

penicillin binding protein 6b

-1.22

-0.90

emrA1

multidrug resistance secretion protein

-0.64

-0.11

mepA1

murein DD-endopeptidase, penicillin-insensitive

-0.68

-0.19

mreB2

regulator of ftsI, penicillin binding protein 3, septation function

-0.53

-0.44

mreC

rod shape-determining protein

-0.29

-0.39

napF

Fe-S ferredoxin-type protein

-0.59

-0.14

napG

ferredoxin-type protein

-0.39

-0.20

napH

ferredoxin-type protein

-0.37

-0.20


1Acid up-regulated with aeration [2]

2Base up-regulated with aeration [2]

Hayes et al. BMC Microbiology 2006 6:89   doi:10.1186/1471-2180-6-89

Open Data