Table 3 |
||||
|
Meta-regression analysis to determine sources of heterogeneity |
||||
|
Covariate |
Coefficient |
P-value |
Relative diagnostic odds ratio (RDOR) |
95% confidence interval |
|
|
||||
|
Intercept |
3.248 |
0.0052 |
---- |
---- |
|
Threshold (S) |
- 0.072 |
0.4522 |
---- |
---- |
|
Case control vs. cross-sectional design |
- 0.292 |
0.5219 |
0.75 |
(0.30 – 1.85) |
|
Blinded vs. unblinded studies |
0.441 |
0.2795 |
1.55 |
(0.69 – 3.48) |
|
Chemical vs. other DNA extraction methods |
- 0.209 |
0.5877 |
0.81 |
(0.38 – 1.74) |
|
IS6110 vs. other target sequences |
1.055 |
0.0074 |
2.87 |
(1.34 – 6.16) |
|
Nested vs. regular amplification protocols |
1.196 |
0.0135 |
3.31 |
(1.29 – 8.49) |
|
Probe vs. gel-UV detection methods |
0.157 |
0.7222 |
1.17 |
(0.49 – 2.81) |
|
Sputum smear positive/both vs negative |
0.242 |
0.8146 |
1.27 |
(0.16 – 9.88) |
|
|
||||
|
Intercept: constant term in the model S: indicator of threshold (logit TPR+logit FPR); TPR: true positive rate; FPR: false positive rate RDOR: relative diagnostic odds ratio (obtained by exponentiating the model coefficients) |
||||
|
Flores et al. BMC Microbiology 2005 5:55 doi:10.1186/1471-2180-5-55 |
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