Table 3

Meta-regression analysis to determine sources of heterogeneity

Covariate

Coefficient

P-value

Relative diagnostic odds ratio (RDOR)

95% confidence interval


Intercept

3.248

0.0052

----

----

Threshold (S)

- 0.072

0.4522

----

----

Case control vs. cross-sectional design

- 0.292

0.5219

0.75

(0.30 – 1.85)

Blinded vs. unblinded studies

0.441

0.2795

1.55

(0.69 – 3.48)

Chemical vs. other DNA extraction methods

- 0.209

0.5877

0.81

(0.38 – 1.74)

IS6110 vs. other target sequences

1.055

0.0074

2.87

(1.34 – 6.16)

Nested vs. regular amplification protocols

1.196

0.0135

3.31

(1.29 – 8.49)

Probe vs. gel-UV detection methods

0.157

0.7222

1.17

(0.49 – 2.81)

Sputum smear positive/both vs negative

0.242

0.8146

1.27

(0.16 – 9.88)


Intercept: constant term in the model

S: indicator of threshold (logit TPR+logit FPR); TPR: true positive rate; FPR: false positive rate RDOR: relative diagnostic odds ratio (obtained by exponentiating the model coefficients)

Flores et al. BMC Microbiology 2005 5:55   doi:10.1186/1471-2180-5-55

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