Table 2

Stratified analysis: effect of study and test characteristics on summary diagnostic odds ratios

Subgroup (Number of studies)

Summary DOR (95% CI)


Study design

Case-control (24)

134.4 (65.2 – 213.1)

Cross-sectional (60)

171.1 (106.7 – 274.2)

Blinding

Single or double blinded (29)

90.2 (46.2 – 176.2)

Unblinded or NR (55)

221.2 (137.7 – 355.2)

DNA extraction method

Chemical (55)

153.7 (90.1 – 262.4)

Physical (29)

171.7 (96.2 – 306.6)

Amplification method

PCR/multiplex (68)

139.3 (89.2 – 217.7)

Nested PCR (16)

266.6 (140.8 – 504.6)

Target sequence

IS6110 (54)

236.1 (152.9 – 364.6)

Other target (30)

77.4 (38.2 – 156.9)

Detection method

Probe (49)

130.6 (78.4 – 217.6)

Gel-UV (35)

215.4 (115.1 – 403.2)

Sputum smear status

Pos/Both/NR (78)

161.5 (107.5 – 242.6)

Negative (6)

128.6 (33.4 – 495.1)


Flores et al. BMC Microbiology 2005 5:55   doi:10.1186/1471-2180-5-55

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