Table 3

Distribution of virulence genes and resistance determinants among lineages, CCs and STs ofE. faecium
Lineage/CC/ST MT Isolation site Virulence genes Resistance determinants Transposon genes Plasmidrepgenes Plasmid TAS
esp/intA fms5 fms17 fms19 fms21 pbp5 GyrA ParC aac(6′)-Ie-aph(2″) ant(6′)-Ia tet(M) tet(L) tet(S) intTn916 tndX rep1pIP501 rep2pRE25 rep17pRUM rep18pEF418 reppLG1 reppMG1 axe-txe ω-ε-ζ relBE
Lineage 17
17 (2) 1, 8 W-EFF 2 2 2 2 2 pbp5-30 S84R R61G S80R 1 1 2 2 1 2 2 1 1
386 7 W-MOut 1 1 1 1 1 1 1 1 1 1 1 1 1
Lineage 18
18 (3) 1 (3) D-EFF, W-MOut 3 3 3 1 pbp5-20 S84Y R61G S80I 1 2 3 3 1 2 1 3
262 10 W-EFF 1 1 1 pbp5-25 S84Y R61G 1 1 1 1 1 1 1
574 402 VR 1 1 1 1
Lineage 78
78 (4) 159 (4) W-EFF, W-MOut 4 4 4 4 4 pbp5-28 S84R/Y R61G S80R 2 1 2 2 1 4 4 2 4 4 3
266 (2) 139 (2) W-INF, D-EFF 2 1 2 2 pbp5-24 1 1 2 1 1 2 2 2
323 12 D-MOut 1 1 1 1 pbp5-26 wt R61G S80I 1 1 1 1 1 1 1 1
564 302 D-EFF 1 1 1 1 pbp5-29 S84I R61G S80R 1 1 1 1 1 1 1
653 302 W-EFF 1 nd S84I R61G S80R 1 1 1
CC5
29 (2) W-EFF, W-MOut 2 1 1 2 1
66 W-MOut 1 1 1 1 1 1 1
97 W-EFF 1 wt R61G S80R 1 1
123 W-EFF 1 1 wt R61G 1 1 1
148 W-MOut 1 pbp5-30 wt R61G S80R 1 1 1 1 1
168 W-MOut 1 1 pbp5-31 1 1 1 1 1 1 1 1 1
505 W-EFF 1 wt R61G 1 1
588 D-MOut 1 pbp5-30 1 1 1 1 1 1
635 D-EFF 1 1 1 1
636 W-EFF 1 wt R61G 1
637 W-EFF 1 1 1 wt R61G 1 1
638 W-EFF 1 wt R61G S80I 1
642 W-EFF 1 1 1 1 1
645 D-EFF 1 1 1 1 1
646 W-EFF 1 1 1 1 1
649 W-BR 1 1 1 pbp5-32 wt R61G 1
650 (3) D-EFF 3 3 pbp5-27 2 2 2 1 1 3
CC 9
8 D-EFF 1 1 1 1 1 1 1 1 1 1 1
640 W-EFF 1 1 1 1 1
CC 22
21 W-EFF 1 1 1 1 1 1 1 1
22 W-EFF 1 1 1 1 1 1
25 W-EFF 1 1 pbp5-32 wt R61G 1 1 1
32 (3) W-EFF 3 3 1 wt R61G 2 1
92 W-EFF 1 1 1 1 1
441 W-EFF 1 1 1 1 1 1 1 1
533 W-EFF 1 1 1
633 W-EFF 1 1 1 1 1
644 D-EFF 1 1 1 1 1
CC27
652 W-EFF 1 1 1 1
CC46
47 VR 1 1 1 1
69 D-EFF 1 1 1 1 1 1
CC94
94 W-MOut 1 1 1 1
361 (4) D-EFF, D-MOut 3 4 4 4 pbp5-29 1 1 1 4 1
CC296
296 W-EFF 1 1
CC639
639 W-EFF 1 1 1 1 1
CC648
634 W-EFF 1 1 1 1 1
648 W-EFF 1 1 1 1 1
Doubletons
632 W-MOut 1 1 1
Singletons
264 W-INF 1 1 1 1 1 1 1
641 D-EFF 1 1 1 1
643 W-EFF 1 1 1 1 1 1
647 W-MOut 1 1 1 1 1
651 D-EFF 1 1 1 1 1 1
654 VR 1 1 1 1 1 1
All (69) 8 57 49 29 46 6 17 20 17 1 9 4 39 27 14 7 55 2 12 10 5

CC, clonal complex; ST, sequence type; MT, MLVA-type; nd, not determined due to lack of amplification of the pbp5 gene; wt, wild-type; STs associated with MDR phenotype in bold.

Abbreviations of sampling points’ locations and their description provided in Figure 1.

Sadowy and Luczkiewicz

Sadowy and Luczkiewicz BMC Microbiology 2014 14:66   doi:10.1186/1471-2180-14-66

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