Sequence of KdpD from V. cholerae. Amino acids labeled in green in the regions H, N, G1, F, G2 are conserved in different species . Labeled in red is threonine 283 which is exchanged by methionine in the dominant mutations of the resistant strains. Amino acids labeled in blue indicate the positions that are modified in four additional mutants (L73P, P341H, E393K and E393G).
Sergeev et al. BMC Microbiology 2014 14:49 doi:10.1186/1471-2180-14-49