Table 2

Isoniazid resistance- associated mutations detected in M. tuberculosis study isolates
Gene N° of isolates tested of isolates with indicated genotype Nucleotide change Amino acid change of mutated isolates according to INH resistance level
Low level (0.2 μg/ml) High level (1 μg/ml)
katG 44 INHR 18 315AGC → ACC Ser → Thr 2 16
1 315AGC → AAC Ser → Asn 0 1
1 Partial deletion NA 0 1
24 WT NA 0 0
100 INHS 0 WT NA NA NA
fabG1-inhA regulatory region 44 INHR 13 -15C → T NA 10 3
5 -47G → C NA 0 5
26 WT NA 0 0
100 INHS 24 -47G → C NA NA NA
3 -102C → T NA NA NA

NA = not applicable; WT = wild type; INHR = isoniazid resistant isolate; INHS = isoniazid sensitive isolate; N°: number.

Tekwu et al.

Tekwu et al. BMC Microbiology 2014 14:113   doi:10.1186/1471-2180-14-113

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