Open Access Research article

Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility

Andrea Jansen1, Christiane Szekat1, Wiebke Schröder2, Christiane Wolz2, Christiane Goerke2, Jean C Lee3, Michael Türck1 and Gabriele Bierbaum1*

Author Affiliations

1 Institut für Medizinische Mikrobiologie, Immunologie und Parasitologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany

2 Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Universität Tübingen,D-72076, Tübingen, Germany

3 Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115, USA

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BMC Microbiology 2013, 13:65  doi:10.1186/1471-2180-13-65

Published: 22 March 2013

Additional files

Additional file 1:

Gene expression data.pdf. Table S1. Genes differentially expressed in the hVISA/MRSA strain SA137/93A and the related VSSA/MRSA control strain SA1450/94. Table S2. Genes differentially expressed in the VISA/MSSA strain SA137/93G and the VSSA/MRSA control strain SA1450/94. Datasets of 4 microarray experiments (Full Genome Chip sciTRACER, Scienion AG, Berlin, Germany) were normalised by applying the LOWESS algorithm and subsequently consolidated using acuity 3.1 software (Axon instruments). Significant changes in gene expression were identified with SAM (significance analysis of microarrays; www-stat.stanford.edu/~tibs/SAM/index.html) software using the one class response type and a false discovery rate of <1%.

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