JNK pathway is activated in osteoblasts upon repeated P. gingivalis infection. A.P. gingivalis infected osteoblasts demonstrated stronger expression of phosphorylated JNK than uninfected control cells from day 7 to 21. Actin is the loading control. B. Quantitative densitometric analysis showing that the p-JNK/JNK ratio was significantly higher in infected osteoblasts compared with control cells. Abbreviations: PG, P. gingivalis; Ctrl, control, non-infected osteoblasts; D, day; JNK, c-Jun N-terminal kinase; p-, phosphorylated. * denotes P < 0.05.
Zhang et al. BMC Microbiology 2013 13:5 doi:10.1186/1471-2180-13-5