Table 4

Gene expression (3 h) under hyphae inducing culture conditions (medium supplemented with 10% fetal calf serum, with culture incubation at 37ºC)
Gene Untreated C. albicans Amphotericin B KSL-W 25 μg/ml KSL-W 100 μg/ml
Fold change1 Fold change1 p-value2 Fold change1 p-value2 Fold change1 p-value2
SAP2 0.99 3.36 0.003 0.78 0.02 0.62 0.003
SAP4 0.96 2.41 0.02 0.44 0.0002 0.24 < 0.0001
SAP5 1.00 0.49 0.0007 0.83 0.03 0.01 < 0.0001
SAP6 1.00 2.56 0.01 0.30 < 0.0001 0.11 < 0.0001
EAP1 1.00 6.06 < 0.001 1.06 0.4 0.99 0.8
EFG1 1.00 1.09 0.6 0.55 0.0004 0.66 0.02
NRG1 1.00 2.45 0.01 0.66 0.0006 0.64 0.0005
HWP1 1.00 0.0055 < 0.001 0.078 < 0.0001 0.0035 < 0.0001

1Fold change was calculated by PCR product of the gene of interest/the PCR product of ACT1 (the house keeping gene), and normalized to the negative control of untreated C. albicans where the expression was considered equal to 1.

2P-values were obtained after comparison of test to negative control (untreated C. albicans).

Theberge et al.

Theberge et al. BMC Microbiology 2013 13:246   doi:10.1186/1471-2180-13-246

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