Table 1

Annotated ESTs up and down regulated genes of Paracoccidioides yeast cells treated with OenB by 90 and 180 min
Functional category Gene product Paracoccidioides acession numbera e-value Number of occurrence
90 min 180 min
Metabolism
    Amino acids metabolism Alanine glyoxylate aminotransferase (AGX1) PAAG_03138.1 1e-152 +2 -1
Hexokinase 1 (HXK1) PAAG_01377.1 2e-48 +2
Urease (URE) PAAG_00954.1 0.0 +1
    Carbohydrate metabolism Betaine aldehyde dehydrogenase (BADH) PAAG_05392.1 0.0 -13 -16
β glucosidase (BGLU) PAAG_04545.1 0.0 +1
Cysteine desulfurase (NFS1) PAAG_05850.1 2e-122 +4 -7
Trehalose phosphatase (TPS1) PAAG_06703.1 1e-165 +20
    Fatty acid metabolism C-5 sterol desaturase (ERG 3) PAAG_03651.1 1e-166 -4
NADP-dependent leukotriene B4 12-hydroxydrogenase (LTB4DH) PAAG_05416.1 5e-179 +1
Fatty acid elongase (GNS1/SUR4) PAAG_08553.1 0.0 +2
    Polysaccharide biosynthesis Glutamine synthetase (GLN1) PAAG_07003.1 0.0 +11 +1
Energy
    Fatty acid β-oxidation Acyl-CoA dehydrogenase (ACAD) PAAG_03490.1 2e-85 +1
    Energy generation Glucose methanol choline oxidorreductase (GMCO) PAAG_08146.1 0.0 +3
Morphology β glucan synthesis associated protein (KRE6) PAAG_00091.1 2e-36 +3
α 1,6 mannosyltransferase (OCH1) PAAG_01658.1 0.0 +5
Arp 2/3 complex subunit Arc16 PAAG_03624.1 0.0 +12
Cell morphology protein (PAL1) PAAG_02031.1 0.0 +1
Integral membrane protein (MPV17/PMP22) PAAG_02868.1 4e-87 -6
GYF domain protein PAAG_00627.1 0.0 +5
Transcription C2H2 transcription factor (SEB1) PAAG_03287.1 0.0 +2
C6 transcription factor (CTF1B) PAAG_01359.1 0.0 -15 +54
Fork head box protein D1 (FOXD1) PAAG_07388.1 4e-40 +1
GATA type sexual (NSDD) PAAG_05818.1 3e-127 +22 -4
Histone deacetylase (RPD3) PAAG_06742.1 0.0 +12
RING finger protein (RNF) PAAG_06129.1 0.0 -3 -15
Transcription factor (ATF1) PAAG_01945.1 5e-169 +1
Transcription factor fungi PAAG_02049.1 0.0 +65
Protein RNP domain PAAG_03136.1 6e-98 +2
Transcription factor prr1(HSF1) PAAG_05064.1 6e-89 +1
Transcription factor (STEA) PAAG_00406.1 0.0 +18
Signal transducer Guanine nucleotide binding protein alpha-1 subunit (GPA2) PAAG_04436.1 5e-178 -23
Protein with PYP-likesensor domain (PAS) PAAG_06301.1 0.0 +10 -44
Protein fate Proteasome component (PRE6) PAAG_07802.1 7e-70 +3
Protein synthesis Elongation factor 1-gamma 1 (eEF-1) PAAG_03556.1 0.0 -1
ATP-dependent RNA helicase (eIF-4A) PAAG_00689.1 0.0 +2 -9
Cellular transport, transport facilities and transport routes Calcium-transporting ATPase sarcoplasmic/endoplamic reticulum type (PMR1) PAAG_00774.1 0.0 +1
Ferric-chelate reductase (FRE) PAAG_05370.1 7e-107 +2
Succinate/fumarate mitochondrial transporter (SFC1) PAAG_06563.1 0.0 -4
Membrane biogenesis protein (YOP1) PAAG_00481.1 7e-143 +1
Major facilitator superfamily transporter (MFS) PAAG_01353.1 0.0 -27 -22
Bodown 198 – Major facilitador superfamily transporter PAAG_06077.1 3e-124 -4
Cell cycle and DNA processing Ribonuclease reductase large subunit (RNR1) PAAG_02210.1 5e-175 +1
Arginine N-methyltransferase - SKB1 (PRMT5) PAAG_02402.1 0.0 +52
SH3 domain-containing protein (CYK3) PAAG_02301.1 0.0 +2
Cell rescue, defense and virulence
    Stress Response Phosphatase regulatory subunit (GAC1) PAAG_00128.1 0.0 +10
Heat shock protein (HSP70) PAAG_08003.1 1e-74 -1
    Virulence factor Pathogenesis associated protein (CAP20) PAAG_06538.1 0.0 -21
Functional unclassified proteins Uncharacterized protein family UPF0121 PAAG_00184.1 9e-94 +4
Pleckstrin Homology (PH) domain PAAG_03092.1 0.0 +11
DUF 1688 domain protein PAAG_04190.1 0.0 +154
Unclassified proteins Conserved hypothetical protein PAAG_06834.1 0.0 +25
Conserved hypothetical protein PAAG_07365.1 0.0 +34
Conserved hypothetical protein PAAG_05009.1 0.0 +10 -3
Conserved hypothetical protein PAAG_07364.1 2e-139 +4 +2
Conserved hypothetical protein PAAG_04732.1 0.0 +7
Conserved hypothetical protein PAAG_03559.1 0.0 +2
Conserved hypothetical protein PAAG_02868.1 4e-87 +11
Conserved hypothetical protein PAAG_01170.1 9e-122 +1
Conserved hypothetical protein PAAG_04190.1 0.0 -1
Conserved hypothetical protein PAAG_06925.1 0.0 +1
Conserved hypothetical protein PAAG_08832.1 3e-143 +5
Conserved hypothetical protein PAAG_07770.1 3e-143 +1
Conserved hypothetical protein PAAG_03654.1 2e-70 +63
Conserved hypothetical protein PAAG_00520.1 1e-7 +1
Hypothetical protein PAAG_07199.1 7e-126 +7
Hypothetical protein PAAG_03580.1 0.0 +6
Hypothetical protein PAAG_04733.1 0.0 +3
Hypothetical protein PAAG_06820.1 0.0 +1
Hypothetical protein PAAG_08066.1 7e-71 +27
Hypothetical protein PAAG_05558.1 7e-76 +1
Hypothetical protein PAAG_03580.1 0.0 -1
Hypothetical protein PAAG_03099.1 2e-151 +45
Hypothetical protein PAAG_06251.1 0.0 -3
Hypothetical protein PAAG_01169.1 0.0 +1
Hypothetical protein PAAG_08809.1 0.0 +1

a Accession number at Broad (http://www.broadinstitute.org webcite).

Zambuzzi-Carvalho et al.

Zambuzzi-Carvalho et al. BMC Microbiology 2013 13:227   doi:10.1186/1471-2180-13-227

Open Data