Table 1

COG category of differentially-expressed genes in NCTC 11168 in response to treatment with an inhibitory dose of Ery
COG category No. up-regulated (%)* No. down-regulated (%)* Total No. differentially expressed genes
Amino acid transport and metabolism 14 (11.11%) 12 (9.52%) 26
Carbohydrate transport and metabolism 1 (2.94%) 4 (11.76%) 5
Cell cycle control, mitosis and meiosis 2 (14.29%) 2 (14.29%) 4
Cell motility 10 (19.23%) 2 (3.85%) 12
Cell wall/membrane biogenesis 3 (2.52%) 9 (7.56%) 12
Coenzyme transport and metabolism 7 (10.14%) 3 (4.35%) 10
Defense mechanisms 2 (8.70%) 0 (0.00%) 2
Energy production and conversion 6 (6.32%) 30 (31.58%) 36
Function unknown 9 (12.67%) 3 (4.23%) 12
General function prediction only 12 (8.45%) 10 (7.04%) 22
Intracellular trafficking and secretion 0 (0.00%) 1 (2.17%) 1
Inorganic ion transport and metabolism 9 (11.11%) 4 (4.94%) 13
Lipid transport and metabolism 3 (8.57%) 0 (0.00%) 3
Nucleotide transport and metabolism 1 (2.33%) 4 (9.30%) 5
Poorly characterized 32 (6.00%) 19 (3.56%) 51
Posttranslational modification, chaperones 6 (9.23%) 7 (10.77%) 13
Replication, recombination and repair 3 (5.00%) 3 (5.00%) 6
Signal transduction mechanisms 3 (6.67%) 1 (2.22%) 4
Transcription 6 (13.95%) 1 (2.33%) 7
Translation 10 (10.00%) 4 (4.00%) 14
Total 139 119 258

* This percentage was calculated based on the number of the up or down regulated genes in a category to the total number of the genes in that particular category.

Xia et al.

Xia et al. BMC Microbiology 2013 13:133   doi:10.1186/1471-2180-13-133

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