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Open Access Highly Accessed Research article

Gene expression profiling of Mycobacterium avium subsp. paratuberculosis in simulated multi-stress conditions and within THP-1 cells reveals a new kind of interactive intramacrophage behaviour

Andrea Cossu1*, Leonardo Antonio Sechi1, Stefania Zanetti1 and Valentina Rosu12

Author Affiliations

1 Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy

2 Experimental Zooprophylactic Institute of Sardinia, Department of Nuoro, Nuoro, Italy

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BMC Microbiology 2012, 12:87  doi:10.1186/1471-2180-12-87

Published: 30 May 2012

Additional files

Additional file 1:

Additional tables (Tables S1-S4).Table S1. Genes of M. avium subsp. paratuberculosis with significantly up-regulated expression levels in the acid-nitrosative stress (≥2 fold change). Table S2. Genes of M. avium subsp. paratuberculosis with significantly down- regulated expression levels in the acid-nitrosative stress (≤2 fold change). Table S3. Genes of M. avium subsp. paratuberculosis with significantly up-regulated expression levels in the infection of THP-1 cells (≥2 fold change). Table S4. Genes of M. avium subsp. paratuberculosis with significantly down-regulated expression levels in the infection of THP-1 cells (≤2 fold change).

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