Table 1

M. tuberculosis genes found to be associated with CNS invasion/survival in the guinea pig

Gene MT #

Gene Rv #

Description

P value


MT0086

Rv0079

Conserved Hypothetical Protein

5.87E-04


MT0350

Rv0336

Conserved 13E12 Repeat Family Protein

1.99E-03


MT0752

Rv0727c

Possible Aldolase

5.07E-04


MT0779

Rv0755c

PPE Family Protein

1.25E-04


MT0958

Rv0931c

Ser-Thr Protein Kinase (PknD)

1.65E-03


MT1311

Rv1273c

Probable Drug-Transport ABC Transporter

2.71E-04


MT1711

Rv1673c

Conserved Hypothetical Protein

ND


MT1965

Rv1914c

Conserved Hypothetical Protein

ND


MT1982

Rv1932

Probable Thiol Peroxidase Tpx

4.47E-05


MT2456

Rv2387

Conserved Hypothetical Protein

2.53E-04


MT3178

Rv3094c

Conserved Hypothetical Protein

ND


MT3247

Rv3159c

PPE Family Protein

5.87E-05


MT3321

Rv3224

Iron-Regulated Dehydrogenase/Reductase

2.77E-03


MT3461

Rv3353c

Conserved Hypothetical Protein

9.12E-03


Mutants for the above genes were found to be significantly attenuated in the guinea pig CNS, but not lungs, 21 days after intravenous infection. Selected mutants were attenuated greater than 16-fold in the CNS and less than 4-fold in the lung tissue (P < 0.05). Mutants annotated as "ND" were not detected in the brain in quantities detectable by PCR, and were therefore likely highly attenuated in CNS tissue.

Be et al. BMC Microbiology 2012 12:7   doi:10.1186/1471-2180-12-7

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