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Investigations into genome diversity of Haemophilus influenzae using whole genome sequencing of clinical isolates and laboratory transformants

Peter M Power1, Stephen D Bentley2, Julian Parkhill2, E Richard Moxon1* and Derek W Hood13*

Author Affiliations

1 University of Oxford Department of Paediatrics, Medical Sciences Division, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK

2 Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

3 Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

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BMC Microbiology 2012, 12:273  doi:10.1186/1471-2180-12-273

Published: 23 November 2012

Additional files

Additional file 1:

Figure S1. Tree indicating the relatedness of Haemophilus genome sequences based on similarities in their patterns of SNPs. Illumina fastq sequences were mapped against the reference sequence of Hib strain 10810 and the tree was generated using FastTree from the SNP alignments. Some minor differences in strain placement when compared to Mauve analysis reflects those strains with the lowest quantity (and quality) of genome sequence information.

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