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Open Access Highly Accessed Research article

Lateral gene transfer of an ABC transporter complex between major constituents of the human gut microbiome

Conor J Meehan12 and Robert G Beiko2*

Author Affiliations

1 Faculty of Biochemistry and Molecular Biology, Dalhousie University, 5080 College Street, Halifax, NS, B3H 4R2, Canada

2 Faculty of Computer Science, 6050 University Avenue, Halifax, NS, B3H 1W5, Canada

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BMC Microbiology 2012, 12:248  doi:10.1186/1471-2180-12-248

Published: 1 November 2012

Additional files

Additional file 1:

Figure S1. Phylogenetic trees of K02031-K02035 (A-E respectively) showing the spread of gut-associated species. Phylogenetic analysis of each set of sequences from proteins within the peptides/nickel transporter showing the spread of gut-associated species (red terminal branches) throughout each tree.

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Additional file 2:

Table S1. Consistency index between KO trees of gut-associated species and taxonomic ranks. Subtrees for each KO comprising only gut-associated species were examined for consistency between taxonomy and phylogenetic placement.

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Additional file 3:

Figure S2. Phylogenetic tree of gut-associated species for K02031. Phylogenetic analysis of only gut-associated species showing the spread of Faecalibacterium prausnitzii (green) and Clostridium difficile (red) strains.

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Additional file 4:

Figure S3. Phylogenetic analysis of proteins associated with K02031-K02035 within Faecalibacterium prausnitzii. Protein sequences annotated as being part of the nickel/peptides transporter complex (K02031-K02035) within the five strains of F. prausnitzii were found to fall into one of six subtrees within each protein tree. Each subtree corresponds to an operon as listed in Figure 2. IMG gene object ID locus names for sequences are listed beside the strain name. Branch labels correspond to bootstrap values. Branch lengths are not to scale. (PDF 226 kb)

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