Table 2

Macrolide resistance genotypes of 295 isolates of erythromycin-resistant S. pyogenes, indicating the phenotypes and emm/T types detected
Macrolide resistance genotype No. of isolates Phenotypea emm/T typesa
(%) cMLSB iMLSB M
erm(B) 14 (4.7) 14 - - emm6T6 (1b), emm11T11 (5b)
emm28T28 (6c), emm71TNT (1)
emm78T11 (1)
erm(B)/erm(A) 1 (0.3) 1 - - emm12T12
erm(B)/ msr(D) 5 (1.7) 5 - - emm11T11 (1b), emm28T28 (3)
emm88T28 (1)
erm(B)/mef(A) 21 (7.1) 20 - 1 emm4T4 (1), emm28T28 (18)
emm28TNT(1), emm75T25 (1)
erm(B)/ msr(D)/mef(A) 33 (11.2) 8 - 25 emm1T1 (1), emm2T2 (1)
emm4T4 (14), emm6T6 (2)
emm11T11 (2b), emm12T12 (4)
emm28T28 (4), emm75T25 (4)
emm84T25 (1)
erm(B)/ msr(D)/ erm(A) 2 (0.7) 2 - - emm11T11 (2b)
erm(B)/ erm(A)/mef(A) 7 (2.4) 5 2 - emm11T11 (1b), emm28T28 (4)
emm77T28 (1b), emm83TNT (1b)
erm(B)/ msr(D)/mef(A)/ erm(A) 27 (9.2) 2 1 24 emm1T1 (1), emm4T4 (3)
emm11T11 (1), emm12T12 (3)
emm75T25 (14),emm81TB3264(1)
emm84T25 (4)
erm(A)/mef(A) 6 (2.0) 1 1 4 emm2T2 (3), emm28T28 (2)
emm77T28 (1b)
erm(A) 2 (0.7) - 2 - emm3T3/13 (1), emm22T12 (1)
erm(A)/ msr(D) 3 (1.0) - 2 1 emm22T12 (2), emm75T25 (1)
msr(D) 1 (0.3) - - 1 emm3T3 (1)
msr(D)/mef(A) 112 (38.0) - - 112 emm1T1 (6), emm4T4 (62),
emm6T6 (26), emm12T12 (10)
emm28T28 (1), emm75T25 (6)
emm84T25 (1)
msr(D)/mef(A)/ erm(A) 58 (19.7) - - 58 emm1T1 (1), emm4T4 (36)
emm12T12 (2), emm12TNT (1)
emm44T5/27/44 (1), emm75T25 (17)
None gene 3 (1.0) 2 - 1 emm1T1 (1), emm28T28 (1)
emm28TNT (1)
Total 295 (100) 60 8 227

aNo. of GAS isolates. bAll isolates were also resistant to tetracycline, showing co-resistance to both erythromycin and tetracycline. cOne isolate showed co-resistance to both erythromycin and tetracycline.

Rubio-López et al.

Rubio-López et al. BMC Microbiology 2012 12:215   doi:10.1186/1471-2180-12-215

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