Table 2

Time series of macrolide resistance gene presence, sequence types, and serotypes in S. pneumoniae clinical isolates

Time period


1999-2000

2001-2002

2003-2004

2005-2006

2007-2008


Macrolide-resistant S. pneumoniae population

Sequence types (no. isolates)

Serotyp ea (no. tested)

No. isolates

Sequence types (no. isolates)

Serotypea (no. tested)

Sequence types (no. isolates)

Serotypea (no. tested)

Sequence types (no. isolates)

Serotypea (no. tested)


Dual mef(E)/erm(B)-positive

271 (4)

19F (4)

0

320b (2)

19A (2)

320b (19)

19A (16)

320b (24)

19A (21)


1412b,e (1)

19F (1)

1396b (2)

19F (2)

320b,e (2)

19A (1)

1459b (1)

NT


3039b,g (1)

19F (1)

271 (1)

19F (1)

271 (2)

19F (2)

NFb (1)

19A (1)


NFb,c (2)

19F (2)

NT (1)

19F (1)

1459b (2)

19F (1)

NTe (1)

NT


NTd (1)

19F (1)

3039b (1)

19F (1)


1396b,e (1)

19F (1)


NFb (3)

19F (2)


NT (1)


Total for time period

9 (39.1%)

6 (40.0%)

31 (58.5%)

27 (67.5%)


mef(E)-positive

236b (2)

19F (2)

0

376 (2)

6A (2)

2705 (3)

33A/F/37 (3)

3280 (3)

NT


13g (1)

NT

1186 (2)

NT

1186 (3)

NT

1379 (2)

6C (2)


156 (1)

6A (1)

1556 (1)

NT

236b (2)

19F (2)

162f (1)

NT


376 (1)

6A (1)

6422 (1)

NT

156 (1)

9V (1)

199 (1)

19A (1)


384f (1)

6B (1)

NTf (1)

6C

199 (1)

19A (1)

344 (1)

NT


384g (1)

6B (1)

558 (1)

35B (1)

1518 (1)

6B (1)


NFg (1)

NT

1379 (1)

6C (1)

NF (1)

6A (1)


NT (2)

NT

3065 (1)

6C (1)


NTf (1)

NT

NFf (1)

19F (1)


NT (1)

6C (1)


NTf (1)

NT


Total for time period

11 (47.8%)

7 (46.7%)

16 (30.2%)

10 (25.0%)


erm(B)-positive

315 (2)

6B (2)

0

63 (1)

15A/15F (1)

63 (5)

15A/15F (5)

63 (2)

15A/15F (2)


3066g (1)

18A/B/C/F (1)

NT (1)

180 (1)

3 (1)


Total for time period

3 (13.1%)

2 (13.3%)

6 (11.3%)

2 (5.0%)


mef(A)-positive

1111 (1)

6C (1)


Total for time

0

0

0

0

1 (2.5%)


Total macrolide resistant/Total no. isolates collected

23/131 (17.6%)

0/34 (0%)

15/54 (27.8%)

53/223 (23.8%)

40/150 (26.7%)


a Serotype deduced by PCR; serotypes in bold are non-vaccine types

b Sequence type is a single locus variant of ST271

c NF, Sequence type not found in MLST database

d NT, Not typed

e Dual-positive with M-phenotype (n = 5)

f mef(E)-positive with MLSB phenotype (n = 6)

g Invasive isolate (n = 5)

Bowers et al. BMC Microbiology 2012 12:12   doi:10.1186/1471-2180-12-12

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