Figure 5 .

ClustalW[47,48]alignment of metal sensing MerR regulators. PbrR (Rmet_5946), PbrR691 (Rmet_2302) and PbrR710 (Rmet_3456) are from the genome of C. metallidurans CH34. CadR is from Pseudomonas stutzeri A1501. ZntR, and CueR are from the E. coli K-12 genome, and MerR is from Tn501. The helices of the Helix-Turn-Helix DNA binding domain are boxed. Essential cysteine residues (Cys14, Cys79, and Cys134 –PbrR numbering) required for activation of PpbrA by PbrR are marked. Key to symbols: * = residues in that column are identical in all sequences in the alignment. The symbol : = conserved substitutions have been observed, and the symbol . = semi-conserved substitutions are observed.

Hobman et al. BMC Microbiology 2012 12:109   doi:10.1186/1471-2180-12-109
Download authors' original image