Table 1

Characteristics and mechanisms of the 34 fusidic acid-resistant MRSA clinical isolates

Isolate

Specimen

FA

MIC

(μg/ml)

VAN

MIC

(μg/ml)

LZD

MIC

(μg/ml)

OXA

MIC

(μg/ml)

RIF

MIC

(μg/ml)

fusC

Polymorphism(s)

in EF-G

PFGE

patterns


1

Pus

8

1

1

>2

< = 0.5

-

H457Y

A1

2

Pus

32

1

2

>2

< = 0.5

+

-

A1

3

Pus

8

1

1

>2

< = 0.5

+

-

A1

4

Sputum

16

1

2

>2

< = 0.5

+

H457Y

A1

5

Sputum

32

2

2

>2

>2

+

-

A1

6

Pus

16

1

1

>2

>2

+

-

A2

7

Pus

8

1

1

>2

< = 0.5

+

-

A3

8

Sputum

16

1

1

>2

< = 0.5

+

-

A3

9

Pus

16

1

1

>2

< = 0.5

-

G556S

A3

10

Sputum

16

1

1

>2

< = 0.5

-

H457Y, G556S

A3

11

Ascites

8

1

1

>2

< = 0.5

-

H457Y

A3

12

Pus

64

2

2

>2

< = 0.5

+

-

A3

13

Sputum

64

2

2

>2

< = 0.5

-

H457Y

A3

14

Pus

16

1

1

>2

< = 0.5

+

-

A3

15

Blood

4

1

1

>2

< = 0.5

+

-

A3

16

Pus

8

1

1

>2

< = 0.5

+

-

A3

17

Blood

8

1

1

>2

< = 0.5

+

-

A3

18

Blood

16

1

1

>2

< = 0.5

+

-

A3

19

Blood

16

1

1

>2

< = 0.5

+

-

A3

20

Pus

2

2

1

>2

< = 0.5

+

-

A3

21

Urine

2

2

2

>2

< = 0.5

-

H457Y, G556S

A3

22

Sputum

2

2

2

>2

< = 0.5

+

-

A3

23

Pus

16

2

1

>2

>2

-

H457Y

A4

24

Pus

2

1

1

>2

< = 0.5

+

-

A5

25

Urine

16

1

1

>2

< = 0.5

+

-

A6

26

CVP tip

8

1

2

>2

< = 0.5

+

-

A6

27

Pus

2

2

2

>2

< = 0.5

+

-

A6

28

Sputum

16

1

2

>2

< = 0.5

+

-

A7

29a

Pus

8

1

2

>2

< = 0.5

+

-

A8

30

Sputum

16

1

2

>2

< = 0.5

+

-

A9

31

Pus

16

1

2

>2

< = 0.5

-

H457Y, R659L

A9

32

Sputum

8

1

2

>2

< = 0.5

+

-

A9

33

Blood

16

1

1

>2

< = 0.5

-

G556S

A9

34

Pus

2

2

2

>2

< = 0.5

+

-

A9


FA, fusidic acid; VAN, vancomycin; LZD, linezolid; OXA, oxacillin; RIF, rifampin

a nonsense mutation in fusC (S175 was encoded by TAA rather than TCA)

Chen et al. BMC Microbiology 2011 11:98   doi:10.1186/1471-2180-11-98

Open Data