Table 3

Characteristics of bla locus alleles

Gene

Allele No.

Frequency

SNPc)

Amino acid substitutions



MRSAa)

MSSAb)

Silent

Conservative

Missense

Nonsense


1

0.43

0.21

0

0

0

0

0

2

0.02

0

1

0

0

1

1

3

0.07

0.04

9

4

2

2

0

4

0.04

0

9

4

2

3

0

5

0.06

0

7

2

2

3

0

6

0.11

0.46

13

8

2

3

0

blaZ

7

0.02

0

12

6

2

4

0

8

0.10

0.04

11

6

2

3

0

9

0.07

0.08

20

9

2

7

0

10

0.04

0.04

19

8

2

7

0

11

0.06

0.04

24

11

3

8

0

12

0

0.04

24

11

2

8

0

13

0

0.04

12

7

2

3

0


1

0.33

0.45

0

0

0

0

0

2

0.15

0.25

6

5

0

1

0

3

0.19

0.15

1

0

0

1

0

4

0.19

0.05

4

3

0

1

0

blaI

5

0.04

0

7

5

0

2

0

6

0.07

0

4

3

0

1

0

7

0.04

0

5

4

0

1

0

8

0

0.05

3

1

1

1

0

9

0

0.05

1

0

0

1

0


1

0.26

0.24

0

0

0

0

0

2

0.07

0

19

9

4

6

0

3

0.10

0

18

7

4

6

0

4

0.07

0.06

35

15

9

10

0

5

0.07

0.18

35

15

7

11

0

6

0.07

0.12

17

6

4

6

0

blaR1

7

0.07

0.06

24

10

7

7

0

8

0.03

0

33

12

6

12

0

9

0.16

0

31

11

6

11

0

10

0.13

0.24

32

12

6

11

0

11

0

0.06

20

9

5

7

0

12

0

0.06

34

16

6

10

0


a) The total number of MRSA strains whose blaZ, blaI and blaR1 genes were analyzed is 54, 27 and 31, respectively.

b) The total number of MSSA strains whose blaZ, blaI and blaR1 genes were analyzed is 24, 20 and 17, respectively.

c) For each allele, the SNP were counted taking as reference Tn552 bla sequences (allele 1).

Milheiriço et al. BMC Microbiology 2011 11:76   doi:10.1186/1471-2180-11-76

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