Table 3

Fluorescent in situ hybridization (FISH) scores on intestinal specimens from 24 NEC patients.

Patient number

Tissue

Days of antibiotic5

NEC score

EUB338

Enterobateria

Clostridium1

Actinobactere

Lactobacillus

Bifidobateria


25

small intestinal

3

14

0

0

0

0

0

0

264

small intestinal

4

13

0

0

0

0

0

0

94

small intestinal

1

10

1

1

0

0

0

1

2

small intestinal2

1

15

1

0

0

2

0

0

6

small intestinal

17

11

1

2

0

0

2

0

8

small intestinal

1

12

1

0

0

0

0

0

12

large intestinal

5

17

1

0

0

2

0

0

14

small intestinal

15

13

1

1

1

1

2

0

15

small intestinal2

5

19

1

0

0

2

0

0

164

small intestinal

4

6

1

1

1

1

0

0

27

small intestinal

4

8

1

1

0

0

0

0

1

small intestinal

6

5

2

2

0

1

2

0

33

large intestinal

1

11

2

2

2

2

0

2

7

small intestinal

5

13

2

2

0

1

0

0

104

small intestinal2

4

13

2

1

0

0

2

0

114

small intestinal

7

7

2

1

0

0

2

0

17

small intestinal

11

15

2

2

0

0

1

0

183

small intestinal2

12

15

2

2

1

1

0

1

19

small intestinal

4

19

2

2

0

1

1

0

20

small intestinal

11

13

2

1

0

1

2

0

21

small intestinal2

2

12

2

2

0

1

0

0

224

small intestinal

1

13

2

2

0

1

0

0

23

small intestinal

4

15

2

2

0

0

0

0

244

large intestinal

2

13

2

2

0

1

0

0


The score was: 0: few bacteria;1: moderate number of bacteria; 2: high number of bacteria.

1 The Clostridium probe is a mixture of four specific probes targeting Clostridium species: C. perfringens, C. difficile, C. butyricum and C. parputrificum

2 The neonates had tissues from both the small intestine and large intestine removed but FISH analysis was only done on the small intestinal tissues

3 Pneumatosis intestinalis verified by histopathology

4 Dead after the surgical operation

5 Before NEC diagnose

Smith et al. BMC Microbiology 2011 11:73   doi:10.1186/1471-2180-11-73

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