Table 1

Antimicrobial susceptibility, QRDR mutations and sequence types of quinolone-resistant E. coli isolates

Strains

Nali-dixic acid MIC

mg/L

Resistance pattern*

QRDR mutations

Horizontally acquired quinolone resistance genes

Allelic profile

Sequence type (ST)

ST complex



Δ GyrA

Δ ParC

adk

fumC

gyrB

icd

mdh

purA

recA


2006


06/073

64

AC NSLTR

none

none

none

6

19

15

16

9

8

7

443

205


06/079

128

AC NSLTR

none

none

none

6

65

2

25

5

5

2

1466

none


06/137

128

AC NSLTR

none

none

none

6

65

2

25

5

5

2

1466

none


06/065

128

A NSLTR

none

none

qnrS1

6

7

5

1

8

18

2

206

206


06/036

256

AC NSLTR

none

none

none

6

8

4

1

9

48

7

210

none


06/027

64

C N

S83L

none

qnrB2

10

11

4

8

8

8

2

10

10


06/045

64

A NSLTR

S83L

none

none

10

174

4

8

8

8

2

1286

10


06/056

128

A NSLTR

S83L

none

none

112

11

5

12

8

8

86

542

none


06/068

128

AC NSLTR

S83L

none

none

76

43

19

37

30

1

2

1465

none


06/151

>1024

ACPNSLTR

S83L, D87N

none

none

43

41

15

18

11

7

6

101

101


06/154

>1024

ACPN TR

S83L, D87N

none

qnrB1

43

41

15

18

11

7

6

101

101


06/030

>1024

ACPN LTR

S83L, D87N

S80I

qnrS1

10

11

4

8

8

13

73

617

10


06/110

>1024

ACPNSLTR

S83L, D87N

S80I

none

92

4

87

96

70

58

2

648

none


06/148

>1024

A PNSLTR

S83L, D87N

S80I

none

92

4

87

96

70

58

2

648

none


06/026

>1024

ACPNSLTR

S83L, D87N

S80I, N105S

none

56

6

22

16

11

1

7

455

None


06/112

>1024

ACPN LTR

S83L, D87N

S80I, E84K

none

6

29

32

16

11

8

44

156

156


2007

none


07/16a

256

A PNSLT

none

none

none

6

95

4

18

11

7

14

1304

none


07/34

128

AC N LTR

none

none

none

10

11

4

12

7

8

2

1467

none


07/12

64

NSLT

S83L

none

none

10

11

4

8

8

8

2

10

10


07/37

128

A N L R

S83L

T66I

none

10

11

4

8

8

8

2

10

10


07/SHA

>1024

A PNSLTR

S83L, D87N

none

none

6

11

95

104

8

7

2

450

none


07/375

>1024

A PNSLTR

S83L, D87N

S80I

qepA

10

11

4

8

8

8

2

10

10


07/337

>1024

A PN LTR

S83L, D87N

S80I

none

10

11

4

8

8

8

2

10

10


07/282

>1024

ACPNSLTR

S83L, D87N

E84K

qepA

6

29

32

16

11

8

44

156

156


07/24A

>1024

ACPNSLTR

S83L, D87N

S80I, E84G

qnrB1

85

88

78

29

59

58

62

354

354


2008


08/54

64

AC NSLTR

none

none

none

6

99

22

1

8

7

2

1479

206


08/23

64

ACPNSLTR

none

none

none

10

29

4

8

8

8

44

1473

156


08/43

128

A NSLTR

none

none

none

6

7

14

1

8

18

2

1471

l206


08/33

>1024

ACPNSLTR

none

none

qnrS1

6

11

14

8

8

6

6

1469

None


08/91

>1024

ACPNSLTR

none

none

none

10

11

4

1

8

9

2

227

10


08/101

64

A NSLTR

S83A

none

qnrS1

10

11

4

1

8

9

2

227

10


08/78

128

ACPNSLTR

S83L

none

qnrS1

10

11

4

8

8

8

2

10

10


08/90

256

ACPNSLTR

S83L, D87N

S80I

none

6

4

12

1

20

18

7

410

23


08/11

>1024

A PNSLTR

S83L, D87N

S80I

none

6

6

5

26

11

8

6

1468

none


08/26

>1024

A PN LTR

S83L, D87N

S80I

qnrS1

10

11

4

8

8

8

2

10

10


08/87

>1024

A NSLTR

S83L, D87N

S80I

none

10

11

4

8

8

8

2

10

10


08/84

>1024

A NSLTR

S83L, D87N

S80I

qnrS1

10

11

4

8

8

8

2

10

10


08/93

>1024

A PNSLTR

S83L, D87N

S80I

none

10

11

4

8

8

8

2

10

10


08/17

>1024

ACPNSLTR

S83L, D87N

S80I, E84V

none

53

40

47

13

36

28

29

131

none


08/39

>1024

ACPNSLTR

S83L, D87N

S80I, A108V

none

92

40

87

96

70

8

29

1470

none


*A = Ampicillin, C = Chloramphenicol, P = Ciprofloxacin, N = Nalidixic acid, S = Streptomycin, L = Sulphonamide, T = Tetracycline R = Trimethoprim

Namboodiri et al. BMC Microbiology 2011 11:44   doi:10.1186/1471-2180-11-44

Open Data