Open Access Highly Accessed Research article

Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis

Margrete Solheim1*, Mari C Brekke1, Lars G Snipen2, Rob JL Willems3, Ingolf F Nes1 and Dag A Brede1

Author Affiliations

1 Laboratory of Microbial Gene Technology and Food Microbiology, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, N-1432 Ås, Norway

2 Section for Biostatistics, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, N-1432 Ås, Norway

3 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

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BMC Microbiology 2011, 11:3  doi:10.1186/1471-2180-11-3

Published: 4 January 2011

Additional files

Additional file 1:

BLAST comparison of E. faecalis genomes. Data from BLAST comparison of 24 E. faecalis draft genomes with the annotated genes of strain V583.

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Additional file 2:

V583 genes which were identified as significantly enriched among CC2-strains in the present study. A list of V583 genes which were identified as significantly enriched among CC2-strains in the present study.

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Additional file 3:

PCR screening. An overview of results from PCR screening of a collection of E. faecalis isolates.

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Additional file 4:

Enrichment analysis of CC6 non-V583 genes by Fisher's exact test. An overview of the presence non-V583 genes in 24 E. faecalis draft genomes CC6 including data from enrichment analysis by Fisher's exact test.

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Additional file 5:

Amino acid alignment of HMPREF0346_1863 in Enterococcus faecalis HH22 and its homologue in E. faecalis TX0104. An amino acid alignment of HMPREF0346_1863 in Enterococcus faecalis HH22 and its homologue in E. faecalis TX0104.

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