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Impact of sub-inhibitory antibiotics on fibronectin-mediated host cell adhesion and invasion by Staphylococcus aureus

Jean Philippe Rasigade12, Abdelmalek Moulay12, Yannick Lhoste12, Anne Tristan12, Michele Bes12, François Vandenesch12, Jerome Etienne12, Gerard Lina12, Frederic Laurent12 and Oana Dumitrescu123*

Author Affiliations

1 INSERM, U851, Lyon 69008, France

2 Centre National de référence des Staphylocoques, Faculté de Médecine Lyon Est, Université de Lyon, Lyon 69008, France

3 Centre National de Référence des Staphylocoques, 7 rue Guillaume Paradin, 69372 Lyon cedex 08, France

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BMC Microbiology 2011, 11:263  doi:10.1186/1471-2180-11-263

Published: 14 December 2011

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Additional file 1:

Impact of antibiotics on the growth kinetics of S. aureus strain 8325-4 and correlation analysis between n-fold changes in bacterial density and fibronectin binding. Panel A. Bacterial suspensions were cultivated with or without antibiotics at half-MIC for 2 h as described above. Growth curves with and without antibiotics are represented as Δ log variations of the bacterial density. Panel B. Antibiotics-treated suspensions of S. aureus 8325-4 were assayed for fibronectin binding as described above. Spearman's rank correlation coefficient was calculated and no correlation was found between the bacterial density changes and fibronectin binding measures.

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