Table 4

Comparison of Differentially Expressed Genes in Δfur That Contain a Putative Fur Binding Site with Confirmed Data of Fur Regulation from other Studies and the Possible Involvement of other Transcription Regulators

Genes Regulated by Fur and

containing a putative Fur motifa

Fold Changeb

Published

Evidence of Fur

Regulation

[Ref.]

Published

Evidence of Fur

Binding

[Ref.]c

Published

Evidence of

Control By

Other Regulators

[Ref]d


rlgA

2.8

No

No

map

2.6

No

No

rpsB

4.0

No

No

yajC

3.2

No

No

nrdR

2.5

No

No

cyoE

3.1

Yes [12]

No

Fnr [21]

cyoD

7.1

Yes [12]

No

Fnr [21]

cyoB

8.2

Yes [12]

No

Fnr [21]

cyoA

3.2

Yes [12]

No

Fnr [21]

fepA

10.7

Yes [12,15,16,126-129]

Yes [128,129]

fes

39.8

Yes [12,16,127-129]

Yes [128,129]

entC

6.8

Yes [12,15,130]

Yes [130]

sucC

4.1

No

No

Fnr [21]

gpmA

5.6

Yes [12]

No

cmk

2.7

No

No

STM1013

2.8

No

No

STM1133

-4.2

No

No

Fnr [21]

ydiE

7.4

Yes [12,15]

No

Rcs [131]

nth

2.9

No

No

STM1586

76.1

Yes [15]

No

ldhA

-4.0

No

No

Fnr [21]

ynaF

-37.3

No

No

Fnr [21]

tonB

11.4

Yes [12,15]

Yes [132]

hns

3.1

Yes [29]

Yes [29]

STM1795

5.8

No

No

Fnr [21]

STM2186

-8.8

No

No

Fnr [21]

cirA

4.0

Yes [12,15]

Yes [133]

eutC

-4.1

No

No

Fnr [21]

eutB

-3.2

No

No

Fnr [21]

yffB

2.6

No

No

iroB

4.6

Yes [15,59]

No

iroN

9.1

No

No

sitA

53.8

Yes [15,46,61,134-138]

No

MntR [61]

yggU

3.5

No

No

yqjH

3.8

Yes [12]

No

secY

4.0

Yes [101]

Yes [100]

bfr

3.2

Yes [14,79,88]

No

bfd

5.9

Yes [12,14,15]

No

feoB

11.8

Yes[12,14,63,134,139,140]

No

ArcA and Fnr [141]

STM3600

-6.8

No

No

Fnr [21]

STM3690

-4.2

No

No

Fnr [21]

rpoZ

3.9

No

No

udp

-5.4

No

No

IscS [142]

sodA

9.1

Yes [14,55,82,88,143-148]

Yes [85,146,148]

Fnr, ArcA, IHF, SoxRS [53,81]

yjcD

2.8

No

No

dcuA

-5.8

No

No

aspA

-3.6

Yes [13,15]

No

NarL[149,150]

ArcA [151]

ytfE

10.0

Yes [13]

No

NsrR [99]

fhuF

8.5

Yes [12,13,15]

Yes [11,152,153]


a Genes from the present study that are regulated by Fur and possess a putative Fur-binding motif

bFold change of expression in Δfur relative to the wt 14028s

c Evidence of direct Fur binding the regulatory region of the gene

d Regulation by other transcription factors besides Fur

Troxell et al. BMC Microbiology 2011 11:236   doi:10.1186/1471-2180-11-236

Open Data