Table 1

P. aeruginosa genes with enhanced expression at pH 7.5 vs pH 6.0

PA ID

Gene name

Fold expression pH7.5 vs pH6.0

Regulon

Function

Subsystem


PA1134

2.58

IS

probable membrane protein


PA1148

toxA

2.33

IS

exotoxin A precursor


PA2384

4.78

Hypothetical protein in pyoverdin gene cluster/Fe2+/Zn2+ uptake regulation proteins

Siderophore_Pyoverdine


PA2385

pvdQ

2.56

FUR

Acyl-homoserine lactone acylase PvdQ (EC 3.5.1.-), quorum-quenching

Siderophore_Pyoverdine


PA2386

pvdA

2.99

IS

L-ornithine 5-monooxygenase (EC 1.13.12.-), PvdA of pyoverdin biosynthesis

Siderophore_Pyoverdine


PA2389

pvdR

2.36

IS

pyoverdine-specific efflux macA-like protein

Siderophore_Pyoverdine


PA2390

pvdT

2.01

IS

Pyoverdine efflux carrier and ATP binding protein

Siderophore_Pyoverdine


PA2391

opmQ

1.86

IS

Outer membrane pyoverdine eflux protein

Siderophore_Pyoverdine


PA2392

pvdP

2.98

IS

Pyoverdine biosynthesis related protein PvdP, Twin-arginine translocation pathway signal domain

Siderophore_Pyoverdine


PA2393

pvdM

3.43

IS

Putative dipeptidase, pyoverdin biosynthesis PvdM

Siderophore_Pyoverdine


PA2394

pvdN

3.24

IS

Pyoverdin biosynthesis protein PvdN, putative aminotransferase, class V

Siderophore_Pyoverdine


PA2395

pvdO

2.00

IS

PvdO, pyoverdine responsive serine/threonine kinase

Siderophore_Pyoverdine


PA2396

pvdF

2.53

IS

Pyoverdine synthetase PvdF, N5-hydroxyornithine formyltransferase

Siderophore_Pyoverdine


PA2397

pvdE

3.16

IS

PvdE, pyoverdine ABC export system, fused ATPase and permease components

Siderophore_Pyoverdine


PA2398

fpvA

4.07

IS

Outer membrane ferripyoverdine receptor FpvA, TonB-dependent

Siderophore_Pyoverdine


PA2399

pvdD

3.62

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdD

Siderophore_Pyoverdine


PA2400

pvdJ

3.84

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdJ

Siderophore_Pyoverdine


PA2402

pvdI

4.22

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdI

Siderophore_Pyoverdine


PA2403

4.62

Putative iron-regulated membrane protein

Siderophore_Pyoverdine


PA2404

4.96

Putative thiamine pyrophosphate-requiring enzyme

Siderophore_Pyoverdine


PA2405

5.71

Hypothetical protein in pyoverdin gene cluster

Siderophore_Pyoverdine


PA2406

3.84

Hypothetical protein in pyoverdin gene cluster

Siderophore_Pyoverdine


PA2407

2.34

Cation ABC transporter, periplasmic cation-binding protein, PA2407 homolog

Siderophore_Pyoverdine


PA2408

2.82

ABC transporter in pyoverdin gene cluster, ATP-binding component

Siderophore_Pyoverdine


PA2409

1.69

ABC transporter in pyoverdin gene cluster, permease component

Siderophore_Pyoverdine


PA2410

1.84

ABC transporter in pyoverdin gene cluster, periplasmic component

Siderophore_Pyoverdine


PA2411

2.98

IS

Probable thioesterase involved in non-ribosomal peptide biosynthesis, PA2411 homolog

Siderophore_Pyoverdine


PA2412

3.12

IS

Hypothetical MbtH-like protein

Siderophore_Pyoverdine


PA2413

pvdH

3.04

IS

Pyoverdin biosynthesis protein PvdH, L-2, 4-diaminobutyrate:2-oxoglutarate aminotransferase

Siderophore_Pyoverdine


PA2424

pvdL

3.20

IS

Pyoverdine chromophore precursor synthetase PvdL

Siderophore_Pyoverdine


PA2425

pvdG

4.07

IS

Thioesterase PvdG involved in non-ribosomal peptide biosynthesis

Siderophore_Pyoverdine


PA2426

pvdS

5.21

FUR

Sigma factor PvdS, controling pyoverdin biosynthesis

Siderophore_Pyoverdine


PA2427

6.13

IS

Hypothetical protein PvdY

Siderophore_Pyoverdine


PA4168

fpvB

2.03

Outer membrane ferripyoverdine receptor FpvB, for Type I pyoverdine

Siderophore_Pyoverdine


PA5150

2.44

IS

probable short-chain dehydrogenase


PA0471

fluR

2.75

FUR

probable transmembrane sensor


PA0472

fluI

2.59

FUR

probable sigma-70 factor, ECF subfamily


PA0672

hemO

3.61

FUR

Heme oxygenase HemO, associated with heme uptake

Hemin_transport_system


PA2467

foxR

2.08

FUR

Fe2+-dicitrate sensor, membrane component


PA2468

foxI

2.86

FUR

probable sigma-70 factor, ECF subfamily


PA4227

pchR

4.73

FUR

Transcriptional regulator PchR

Siderophore_pyochelin


PA4467

7.46

FUR

Metal transporter, ZIP family


PA4468

sodM

5.59

FUR

Manganese superoxide dismutase (EC 1.15.1.1)


PA4469

10.90

FUR

FOG: TPR repeat


PA4470

fumC1

7.91

FUR

Fumarate hydratase class II (EC 4.2.1.2)

TCA_Cycle


PA4471

7.01

FUR

FagA protein


PA4515

2.80

FUR

Iron-uptake factor PiuC

Transport_of_Iron


PA4516

1.87

FUR

FOG: TPR repeat, SEL1 subfamily


PA4708

phuT

2.00

FUR

Heme-transport protein, PhuT

Hemin_transport_system


PA4709

2.22

FUR

probable hemin degrading factor

Hemin_transport_system


PA4710

phuR

2.00

FUR

Haem/Haemoglobin uptake outer membrane receptor PhuR precursor

Ton_and_Tol_transport_systems


PA4895

1.47

FUR

Iron siderophore sensor protein

Iron_siderophore_sensor_&_receptor_system


PA4896

3.14

FUR

probable sigma-70 factor, ECF subfamily

Iron_siderophore_sensor_&_receptor_system


PA1911

femR

3.55

sigma factor regulator, FemR


PA1912

femI

5.53

ECF sigma factor, FemI


Romanowski et al. BMC Microbiology 2011 11:212   doi:10.1186/1471-2180-11-212

Open Data