Figure 4.

Multiple sequence alignment of selected fungal IMPDHs. The region including the amino acid residue at position 415 and part of the flap-region (flap-region being spanned by residues 412 - 467) is presented in the figure. The position 415 is tyrosine in all IMPDHs identified prior to this work [1]. Note that the flap region is very variable, with only residue 415Y and key catalytic residues 441R and 442Y completely conserved in all IMPDHs identified prior to this work [1]. Residues conserved among all nine sequences are highlighted in grey. P. brevicompactum IMPDH-B (encoded by mpaF) is used as a reference while referring to position numbers. P, Penicillium; A, Aspergillus.

Hansen et al. BMC Microbiology 2011 11:202   doi:10.1186/1471-2180-11-202
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