Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation
1 Department of Structural and Functional Biology, Federico II University of Naples, MSA, via Cinthia 4, 80126 Napoli, Italy
2 Architecture et Fonction des Macromolécules Biologiques, UMR6098, CNRS and Universités d'Aix-Marseille I & II, Case 932, 163 Av de Luminy, 13288 Marseille cedex 9, France
3 School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
BMC Microbiology 2011, 11:198 doi:10.1186/1471-2180-11-198Published: 5 September 2011
Spore-forming Bacilli are Gram-positive bacteria commonly found in a variety of natural habitats, including soil, water and the gastro-intestinal (GI)-tract of animals. Isolates of various Bacillus species produce pigments, mostly carotenoids, with a putative protective role against UV irradiation and oxygen-reactive forms.
We report the annotation of
CAZy analyses of the genomes of the two pigmented Bacilli, compared to other Bacillus species and validated by experimental data on carbohydrate utilization, biofilm formation and mucin degradation, suggests that the two pigmented Bacilli are adapted to the intestinal environment and are suited to grow in and colonize the human gut.