Additional file 5.

Antibody-mediated targeting of uncoated (-mAb) or Trastuzumab- coated Lm-spa+ in a xenograft mouse tumor model. In Balb/c SCID mice 4T1-HER2 cells were injected s.c. to initiate tumor growth. 14 days later the mice were infected i.v. with 1 × 108 CFU of differently coated Lm-spa+. After 24 h mice were sacrificed and tumors, liver and spleen excised aseptically. Organs were homogenized and plated in serial dilutions. In tumor, liver and spleen no significant differences in the bacterial counts were detected between the uncoated and Trastuzumab coated Lm-spa+.

Format: PDF Size: 18KB Download file

This file can be viewed with: Adobe Acrobat Reader

Heisig et al. BMC Microbiology 2011 11:163   doi:10.1186/1471-2180-11-163